Fig. 1.
Replication of stHIV-1 variants in pig-tailed macaque lymphocytes in vitro. (A) Schematic representation of the viral constructs used in this study, shaded regions indicate sequences from HIV-2ROD or SIVMAC239, as indicated. All HIV-1-derived constructs used the macaque-adapted HIV-1 envelope from SHIVKB9. (B, C) RT activity in culture supernatants (expressed as log10 pg/ml) was measured every 2 or 3 days for 15 days following inoculation of pig-tailed macaque lymphocytes with the indicated viruses. The 2 graphs shown in (B) and (C) represent independent experiments employing 2 different pig-tailed macaque donors.