Fig. 4.

Effect of depletion of CD8+ cells on stHIV-1 replication in vivo. (A) Effect of anti-CD8-antibody infusion on the numbers of CD8+ T cells in peripheral blood, as determined by FACS analyses. Note that analysis of lymph node biopsies at 1 week after antibody infusion revealed that 0%, 8%, and 0.1% of the CD3+ cells were CD8+ for animals PT6356, PT7993, and EP69, respectively. (B) Plasma viremia, measured by RT-PCR in the weeks preceding, during, and following CD8+ T-cell depletion in 3 animals.