Fig. 3.

Circadian misalignment suppressed leptin levels proportionally, with maximum suppression during maximum misalignment (by 12 h on fourth 28-h “day,” indicated in red rectangle) as compared to circadian alignment (indicated in green rectangle). Circles, mean; error bars, SEM; gray area, mean ± SEM on first 28-h day replotted for comparison (circadian alignment); horizontal black bars, scheduled sleep episodes; vertical lines, scheduled awakenings; blue numbers above x-axis, approximate hours of circadian misalignment of the scheduled wake time on each 28-h day.