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ASPP2+/− mice have an increased incidence of γ-irradiation-induced lymphomas. (A) Kaplan–Meier lymphoma-free survival curves for ASPP2+/+ and ASPP2+/− mice after 6.0-Gy or 10.5-Gy (P = 0.024 or P = 0.045, log-rank test) total γ-irradiation delivered in divided weekly fractions starting at 6 weeks old. (B) Kaplan–Meier lymphoma-free survival curves for tet-o-MYC;EμSR-tTA mice (29) after conditional c-Myc expression in an ASPP2+/+ or ASPP2+/− background (P = 0.97, log-rank test).
