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. 2009 Feb 26;106(11):4390–4395. doi: 10.1073/pnas.0809080106

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© 2009 by The National Academy of Sciences of the USA

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Fig. 5. — High-grade thymic T cell lymphomas induced in ASPP2^+/− mice after γ-irradiation. (A) Thymic lymphoma (red arrow) in an ASPP2^+/− mouse. H&E-stained microscopic sections of lymphoma-infiltrated liver, kidney, and lung from this mouse. (B) Immunophenotyping of tumor cells in unfractionated bone marrow from this mouse. A total of 2% of normal myeloid progenitors coexpressed Mac-1 and Gr-1 (Upper Right). A total of 98% of the bone marrow was replaced by tumor cells expressing CD5 and CD8 (Lower), but not B220 (Upper Left), CD4, and Nk1.1 markers (Lower).