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ASPP2+/− MEFs have an attenuated G0/G1 checkpoint. Cell cycle distribution shows an increase in G0/G1-arrested ASPP2+/+ MEFs but not ASPP2+/− MEFs 24 h after 5-Gy γ-irradiation (P = 0.0052 and P = 0.9, unpaired 2-tailed Student's t test, respectively). Mean values of triplicate experiments are shown with SDs.
