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Late (i.e., E14.5–E18.5), but not early (i.e., E8.5–E10.5), placentation steps are altered in Rxraafo mutants. Cross-sections through the thickness of placenta from WT and mutant embryos (genotypes as indicated). C, capillaries; CP, chorionic plate; L, labyrinth; S, spongiotrophoblast; T, labyrinthine trophoblast cell. The yellow brackets in A–D indicate the mean thickness of labyrinthine trabeculae. [Scale bar in F: 40 μm (A–D) and 80 μm (E and F).]
