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Conceptual model of the PDGF receptor signaling network. Cross-talk interactions from PI3K lipid products (3′ PIs) affect Ras-specific GEF (e.g. Grb2–Sos complex) recruitment and activation of MEK kinases, which might or might not be the same as those activated by Ras. It is recognized that those cross-talk effects might entail multiple steps, and that a more refined model would account for the effect of JNK activation on the MKP negative feedback loop.
