Table 3.
Mean incidence of adverse events across randomized controlled trials in patients with Social Anxiety Disorder
| Drug | Adverse Event Mean Percentage (95% Confidence Interval) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Nausea | Asthenia* | Sweating | Somnolence | Insomnia | Dry Mouth | Abnormal Ejaculation |
Libido Decrease |
|
| Escitalopram | 25 (19–32) | 14 (13–15) | 9 (3–15) | 11 (9–12) | 9 (NA) | NR | 8 (4–12) | 6 (5–7) |
| Fluoxetine | NR | 30 (NA) | NR | NR | 47 (NA) | NR | NR | NR |
| Fluvoxamine | 39 (23–55) | 28 (NA) | NR | 27 (18–35) | 32 (31–33) | NR | 11 (9–13) | 9 (6–11) |
| Paroxetine | 25 (21–29) | 19 (16–21) | 13 (9–17) | 15 (9–21) | 15 (11–18) | 15 (7–24) | 18 (12–25) | 9 (7–11) |
| Sertraline | 27 (17–37) | 18 (17–19) | 11 (10–12) | 11 (NA) | 27 (22–33) | 14 (13–15) | 13 (10–16) | 7 (NA) |
| Venlafaxine | 31 (27–34) | 16 (8–24) | 15 (8–22) | 22 (14–29) | 22 (16–28) | 17 (13–21) | 14 (10–17) | 8 (6–11) |
NR = adverse event was not reported among included studies
NA = not applicable; only 1 trial reported this adverse event
*
Asthenia = lack of energy or strength