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. Author manuscript; available in PMC: 2009 Mar 18.
Published in final edited form as: Pharmacol Ther. 2007 Apr 21;116(1):58–76. doi: 10.1016/j.pharmthera.2007.03.008

Fig. 6.

Fig. 6

THP increases anxiety in a shock-paired plus maze paradigm following THP withdrawal in mice. For this study, mice were subjected to withdrawal from their naturally high levels of endogenous THP with a 5α-reductase blocker (finasteride, 50 mg/kg, i.p., 3 days). When tested in the elevated plus maze following a brief shock (left panel), THP decreased open arm time following THP Wd, in contrast to its effect in control mice, where it increased this parameter. (*P<0.05 vs. vehicle, n = 17-26). The total number of arm entries (lower panel) was not altered by any experimental treatment. This anxiogenic effect of THP (right panel) was not observed after THP Wd in δ knock-out mice, implicating δ-GABAR in this paradoxical effect of the steroid.