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Gross accumulation of Aβ in Tg-SwDI mouse forebrain in the presence of different ApoE forms. A–C, Human Aβ accumulation was detected by immunostaining (brown) in the forebrain of 12-month-old Tg-SwDI/muAPOE mice (A), Tg-SwDI/hAPOE3/3 mice (B), and Tg-SwDI/hAPOE4/4 mice (C). Scale bar, 1 mm.
