Table 3.

Factors with Significant Effect on Visual Acuity in a Multiple Regression Linear Model

Factor	Univariate Model of Baseline Visual Acuity and Predictive Factor			Multivariate Model of Baseline Visual Acuity†
	r2	Estimate [Decrease in letter score] (95% C.I.)	P-value*	Cumulative* r2	Estimate [Decrease in letter score] (95% C.I.)	P-value* - Final Model (r2 = 35%)
OCT Central Subfield Thickness (per 100 micron increase)	23%	5.1 (4.1, 6.1)	<.0001	23%	3.7 (2.5, 5.0)	<.0001
Age (per decade increase)	6%	2.9 (1.6, 4.1)	<.0001	29%	3.2 (2.1, 4.3)	<.0001
Fluorescein Leakage in the Center and Inner Subfields‡	14%	3.8 (2.7, 4.9)	<.0001	35%	2.8 (1.7, 3.9)	<.0001
# Thickened OCT Subfields	15%	1.7 (1.3, 2.2)	<.0001	35%	0.1 (−0.5, 0.7)	0.73

^*Adjusted for the correlation within subjects with two study eyes.

^†Additional factors explored not significantly associated with visual acuity in a multivariate model included: Inner zone thickness (within 1500 μ of the center or the macula), retinal volume, cystoid spaces on OCT or fluorescein angiography, subsensory retinal detachment on OCT, number of involved subfields, macular slope (the difference between center point mean thickness and the maximum inner paracentral zone thickness), race, gender, diabetes type, duration of diabetes, HbA1c, treatment for hypertension, hard exudates measured on fundus photos, lens status (phakic or pseudophakic), level of retinopathy measured on fundus photos, hemorrhage and microaneurysms within the grid measured on fundus photos.

^‡Missing for 20 eyes.