Table 4.

Fitting recessive disease models (β is fixed at 1) to ten case-control studies analyzed by Wittke-Thompson, Pluzhnikov and Cox (2005) under the null hypothesis H₀: the genotype is in HWE in the study population.

Study	Genotype Distributions
PubMed ID/Disease/Gene	Patients	Controls	Kp	q	α	γ	Deviance (df=2)	p-value
11468325 / Alzheimer disease /CST3	137−34−8	180−40−8	.06	0.121	0.0585	2.750	7.877	.019
11124296 / Macular degeneration /mEPHX	42−24−32	95−38−33	.01	.299	0.00745	4.827	39.326	<.001
11889073 / Colorectal cancer /MTHFR	28−64−94	114−560−553	.05	.671	0.0448	1.257	9.570	.008
12631667 / Crohn disease /CYP1A1	2−20−129	5−22−122	.05	.892	0.0360	1.489	6.386	.041
9607207 / Hypertension (nephroangiosclerosis) / ACE	6−10−21	8−48−19	.05	.568	0.0314	2.829	7.529	.023
10712418 / Myocardial infarction /TF-1208	227−361−218	197−349−186	.1	.482	0.0954	1.205	6.410	.041
10680782 / Multiple sclerosis /GSTM3	276−97−14	221−64−15	.05	.154	0.0494	1.467	10.044	.007
10430441 / Stroke /NOS3	109−125−31	154−203−36	.15	.351	0.1496	1.022	7.675	.022
11027931 / Venous thrombosis/β-fibrogen	2−6−82	0−22−163	.01	.934	0.00693	1.508	5.116	.077
12426569 /MI /lymphotoxin-α gene	416−504−213	378−512−116	.01	.372	0.00942	1.441	8.566	.014