. Author manuscript; available in PMC: 2009 Mar 19.

Published in final edited form as: Genes Immun. 2008 Jun 5;9(5):462–469. doi: 10.1038/gene.2008.38

Table 2.

FBAT haplotype association analysis for the 5′ ICAM-1 haplotype block in severe malaria phenotypes

Phenotype	Haplotype	Freq.	S	E(S)	Var(S)	P
All severe	ACGCAGG	0.288	444.43	446.08	162.48	0.90
	- - - - - C -	0.241	372.16	379.23	135.87	0.54
	C - - T T - -	0.210	328.81	326.72	122.41	0.85
	- - - - - - A	0.087	149.73	150.40	67.36	0.94
	- T - - - - -	0.053	95.87	90.13	39.40	0.36
CM	ACGCAGG	0.279	248.30	247.77	92.88	0.96
	- - - - - C -	0.234	212.09	221.48	74.32	0.28
	C - - T T - -	0.222	209.42	206.29	73.68	0.72
	- - - - - - A	0.085	91.86	87.62	37.08	0.49
	- T - - - - -	0.062	62.86	60.23	25.49	0.60
SA	ACGCAGG	0.298	132.31	130.89	47.88	0.84
	- - - - - C -	0.227	100.32	102.52	36.75	0.72
	C - - T T - -	0.206	83.27	93.48	33.74	0.08
	- - - - - - A	0.089	43.80	43.79	17.86	1.00
	- T - - - - -	0.052	27.00	23.91	10.41	0.34

Parental haplotype frequency derived from seven 5′ ICAM1 SNPs from rs5490 to rs5496, FBAT statistic ‘S’, expected FBAT statistic ‘E(S)’, variance ‘Var(S)’ and P-value are reported under the additive model for transmissions of the minor allele. Only haplotypes >5% frequency analyzed.