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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Bone. 2008 Dec 16;44(4):537–546. doi: 10.1016/j.bone.2008.11.021

Figure 3.

Figure 3

Serum osteocalcin, osteoblast proliferation, alkaline phosphatase, and osteoclast development in Ebf1−/− mice. (A) Serum was collected from individual (>5) Ebf1−/− and +/+ 4 and 12-week-old mice and osteocalcin measured by specific RIA. (B) Both the production of ALP and the proliferative response (C) by cultured calvarial OBs were similar in Ebf1−/− and +/+ mice (SE were all ≥10%). (D) Bone marrow from Ebf1−/− and +/+ mice was cultured with M-CSF and RANKL and the number of large, TRAP+, multinucleated osteoclasts counted. Values represent the mean ± SE. *Significant decrease in Ebf1−/− mice, p ≤0.01.