Table 2.
List of gene set regulated by NGF in PC12 cells
| Gene | Accession no. | Fold change | Subcellular location | |
| Enzymes | ||||
| rat senescence marker protein 2A gene | SMP2A | X63410 | 303 | Cytoplasm |
| myosin, heavy chain 3 | MYH3 | K03468 | 133 | Cytoplasm |
| lecithin-cholesterol acyltransferase | LCAT | X54096 | 101 | Extracellular Space |
| UDP glucuronosyltransferase 2, polypeptide A1 | UGT2A1 | X57565 | 63 | Cytoplasm |
| contactin 4 | CNTN4 | U35371 | 44 | Plasma Membrane |
| phosphodiesterase 4B, | PDE4B | J04563 | 37 | Cytoplasm |
| gulonolactone (L-) oxidase | GULO | J03536 | 34 | Cytoplasm |
| superoxide dismutase 3 | SOD3 | Z24721 | 28 | Extracellular Space |
| fibronectin 1 | FN1 | X15906 | 28 | Plasma Membrane |
| acetylcholinesterase | ACHE | S50879 | 28 | Plasma Membrane |
| tryptophan hydroxylase 1 | TPH1 | X53501 | 24 | Cytoplasm |
| aldo-keto reductase family 1, member C1 | AKR1C1 | BAA92883 | 10 | Cytoplasm |
| guanine nucleotide binding protein, alpha z | GNAZ | U77485 | 9 | Plasma Membrane |
| aminoadipate aminotransferase | AADAT | Z50144 | 5 | Cytoplasm |
| phospholipase D2 | PLD2 | D88672 | 4 | Cytoplasm |
| N-deacetylase/N-sulfotransferase 1 | NDST1 | M92042 | 3 | Cytoplasm |
| phosphate cytidylyltransferase 2 | PCYT2 | AF080568 | 2 | Cytoplasm |
| peptidylprolyl isomerase A | PPIA | M19533 | -2 | Cytoplasm |
| Rab geranylgeranyltransferase alpha | RABGGTA | L10415 | -2 | Unknown |
| glutathione S-transferase A3 | GSTA3 | X78847 | -3 | Cytoplasm |
| cytochrome P450, 4F4 | CYP4F4 | U39206 | -3 | Cytoplasm |
| 3-hydroxyanthranilate 3,4-dioxygenase | HAAO | D28339 | -3 | Cytoplasm |
| stearoyl-Coenzyme A desaturase 2 | SCD2 | AB032243 | -4 | Cytoplasm |
| aldo-keto reductase family 1, member C3 | AKR1C3 | L32601 | -6 | Cytoplasm |
| myxovirus resistance 2 | MX2 | X52711 | -10 | Nucleus |
| serine dehydratase | SDS | M38617 | -11 | Cytoplasm |
| G-protein coupled receptors | ||||
| calcitonin/calcitonin-related polypeptide alpha | CALCA | V01228 | 136 | Plasma Membrane |
| angiotensin II receptor 1 | AGTR1 | NM_009585 | 50 | Plasma Membrane |
| cholinergic receptor, muscarinic 3 | CHRM3 | AB017656 | -2 | Plasma Membrane |
| parathyroid hormone receptor 1 | PTHR1 | M77184 | -3 | Plasma Membrane |
| Growth factors | ||||
| growth differentiation factor 15 | GDF15 | AJ011970 | 131 | Extracellular Space |
| transforming growth factor beta 1 | TGFB1 | X52498 | 101 | Extracellular Space |
| brain-derived neurotrophic factor | BDNF | X67108 | 89 | Extracellular Space |
| neuregulin 1 | NRG1 | U02324 | -3 | Extracellular Space |
| Ion channels | ||||
| calcium channel, voltage-dependent, beta 2 | CACNB2 | M80545 | 90 | Plasma Membrane |
| glutamate receptor, ionotropic, delta 2 | GRID2 | U08256 | 78 | Plasma Membrane |
| sodium channel, voltage-gated, type II, beta | SCN2B | U37147 | 73 | Plasma Membrane |
| potassium inwardly-rectifying channel J4 | KCNJ4 | X87635 | 51 | Plasma Membrane |
| solute carrier family 9 member 3 | SLC9A3 | M85300 | 40 | Plasma Membrane |
| purinergic receptor P2X, ligand-gated ion channel 2 | P2RX2 | Y10475 | 13 | Plasma Membrane |
| sodium channel, voltage-gated, type I, alpha | SCN1A | M22253 | 12 | Plasma Membrane |
| purinergic receptor P2X-like 1 | P2RXL1 | X92070 | -2 | Plasma Membrane |
| gamma-aminobutyric acid A receptor gamma 2 | GABRG2 | X56313 | -19 | Plasma Membrane |
| Kinases | ||||
| G protein-coupled receptor kinase 5 | GRK5 | NM_005308 | 131 | Plasma Membrane |
| protein kinase, cGMP-dependent, type II | PRKG2 | Z36276 | 68 | Cytoplasm |
| mitogen-activated protein kinase kinase kinase kinase 1 | MAP4K1 | Y09010 | 25 | Cytoplasm |
| calcium/calmodulin-dependent serine protein kinase | CASK | U47110 | 3 | Plasma Membrane |
| discs, large homolog 1 | DLG1 | U14950 | 3 | Plasma Membrane |
| phosphatidylinositol 4-kinase beta | PI4KB | D84667 | 3 | Cytoplasm |
| discoidin domain receptor family member 1 | DDR1 | L26525 | -8 | Plasma Membrane |
| non-metastatic cells 6 | NME6 | AF051943 | -14 | Extracellular Space |
| Peptidases | ||||
| carboxypeptidase A3 | CPA3 | U67914 | 5 | Extracellular Space |
| ADAM metallopeptidase domain 17 | ADAM17 | AJ012603 | 4 | Plasma Membrane |
| Proteasome subunit alpha 1 | PSMA1 | M29859 | 3 | Cytoplasm |
| protein disulfide isomerase family A member 3 | PDIA3 | D63378 | 2 | Cytoplasm |
| caspase 1 | CASP1 | U14647 | -5 | Cytoplasm |
| Phosphatases | ||||
| dual specificity phosphatase 6 | DUSP6 | U42627 | 53 | Cytoplasm |
| protein phosphatase 1 subunit 1A | PPP1R1A | AJ276593 | 18 | Cytoplasm |
| protein tyrosine phosphataser type 11 | PTPN11 | U09307 | -2 | Cytoplasm |
| Transcription regulators | ||||
| jun dimerization protein 2 | JDP2 | U53449 | -2 | Nucleus |
| cAMP responsive element modulator | CREM | Z15158 | -4 | Nucleus |
| Transmembrane receptors | ||||
| cholinergic receptor, nicotinic, beta 1 | CHRNB1 | X74833 | 39 | Plasma Membrane |
| Transporters | ||||
| solute carrier family 1 member 1 | SLC1A1 | U21104 | 238 | Plasma Membrane |
| solute carrier family 22, member 3 | SLC22A3 | AF055286 | 95 | Plasma Membrane |
| gap junction protein, beta 2 | GJB2 | X51615 | 55 | Plasma Membrane |
| solute carrier family 1, member 3 | SLC1A3 | S59158 | 6 | Plasma Membrane |
| solute carrier family 22, member 6 | SLC22A6 | AF008221 | 6 | Plasma Membrane |
| vacuolar protein sorting 33 homolog B | VPS33B | U35245 | 4 | Cytoplasm |
| solute carrier family 30, member 1 | SLC30A1 | U17133 | 3 | Plasma Membrane |
| syntaxin 4 | STX4 | L20821 | 2 | Plasma Membrane |
| murinoglobulin 1 | MUG1 | J03552 | -2 | Extracellular Space |
| ATPase, Cu++ transporting, beta polypeptide | ATP7B | AF120492 | -6 | Cytoplasm |
| Others | ||||
| BCL2/adenovirus E1B interacting protein 3 | BNIP3 | AF243515 | 216 | Cytoplasm |
| natriuretic peptide precursor C | NPPC | D90219 | 109 | Extracellular Space |
| trans-golgi network protein 2 | TGOLN2 | X53565 | 106 | Cytoplasm |
| fibrillin 2 | FBN2 | L39790 | 105 | Extracellular Space |
| amyloid P component, serum | APCS | M83177 | 85 | Extracellular Space |
| zinc finger, matrin type 3 | ZMAT3 | Y13148 | 84 | Nucleus |
| LIM and senescent cell antigen-like domains 1 | LIMS1 | AAA20086 | 75 | Plasma Membrane |
| CD44 molecule | CD44 | U96138 | 61 | Plasma Membrane |
| common salivary protein 1 | LOC171161 | U00964 | 54 | Extracellular Space |
| selectin P | SELP | L23088 | 44 | Plasma Membrane |
| collagen, type XI, alpha 1 | COL11A1 | AJ005396 | 39 | Extracellular Space |
| collagen, type XII, alpha 1 | COL12A1 | U57362 | 28 | Extracellular Space |
| nucleosome assembly protein 1-like 4 | NAP1L4 | AJ002198 | 22 | Nucleus |
| spermine binding protein | SBP | J02675 | 20 | Unknown |
| ribosomal protein L35 | RPL35 | M34331 | 6 | Cytoplasm |
| connector enhancer of kinase suppressor of Ras 2 | CNKSR2 | AF102854 | 5 | Plasma Membrane |
| prolactin family 8, subfamily a, member 81 | PRL8A8 | AB000107 | 4 | Extracellular Space |
| extracellular proteinase inhibitor | EXPI | X13309 | 3 | Extracellular Space |
| fibrinogen gamma chain | FGG | J00735 | 3 | Extracellular Space |
| smooth muscle alpha-actin | ACTA2 | X06801 | 2 | Unknown |
| tropomyosin 1 alpha | TPM1 | M34134 | 2 | Cytoplasm |
| calcineurin binding protein 1 | CABIN1 | AF061947 | -2 | Nucleus |
| crystallin, gamma E | CRYGE | J00716 | -2 | Unknown |
| follistatin-like 1 | FSTL1 | M91380 | -2 | Extracellular Space |
| secreted phosphoprotein 2 | SPP2 | U19485 | -2 | Extracellular Space |
| tachykinin, precursor 1 | TAC1 | M15191 | -2 | Extracellular Space |
| myosin light chain 9 | MYL9 | S77900 | -3 | Cytoplasm |
| ubiquitin B | UBB | X51703 | -3 | Cytoplasm |
| golgin B1 protein | GOLGB1 | D25543 | -6 | Cytoplasm |
| lysosomal-associated membrane protein 1 | LAMP1 | X14765 | -11 | Plasma Membrane |
Gene description names, gene symbols are from IPA Tool; accession numbers are from GenBank