Table 5.
Ingenuity biological function analyses of IL-6-versus NGF-regulated genes in PC12 cells (selected)
| IL-6 regulated genes in PC12 cells | NGF-regulated genes in PC12 cells | |||
| Category | p-value | Molecules | p-value | Molecules |
| Sub-Category or Function annotation | ||||
| Cellular Growth and Proliferation | ||||
| Growth of cells | 2.27 × 10-4 | ACVR2A, AHSG, ANXA1, BCL2L11, BRCA1, CASP1, CDC42, CHRM3, CXCL10, EGR1, FGFR1, GAP43, GDF15, GHR, GRID2, HGF, IGF2R, IRF1, ITGA7, JAK2, MAP2K5, MST1, MT3, MX1, NOS3, NOS2A, PIM3, RARA, SCAMP2, SDC2, STAT1, TIMP1, VDR | 8.82 × 10-3 | ACHE, AGTR1, BDNF, BNIP3, CASP1, CD44, CHRM3, CREM, DDR1, DUSP6, FBN2, FN1, GDF15, GJB2, GRID2, MYL9, NRG1, PDIA3, PTPN11, SLC30A1, TGFB1, TPM1, VPS33B, ZMAT3 |
| Proliferation of cells | 9.06 × 10-7 | ACVR2A, ADCYAP1, ANXA1, AVP, BCL2L11, BRCA1, CALCB, CDC42, CHRM3, CHRM4, CRYAB, CXCL10, EGR1, FGFR1, FRK, GDF15, GHR, GHRH, HGF, IGF2R, IRF1, JAG2, JAK2, KLF6, KLK8, LCN2, MAP2K5, MT3, NFIB, NOS3, NOS2A, NR3C2, PDGFA, RARA, REG1A, REG3A, RNMT, SDC2, ST6GAL1, STAT1, TIMP1, TPM3, USF1, VDR, VIPR1 | 3.82 × 10-3 | AGTR1, AKR1C3, BDNF, CALCA, CD44, CHRM3, DDR1, FN1, GDF15, GRK5, NPPC, NRG1, PPIA, PTPN11, TAC1, TGFB1 |
| Cellular Movement | ||||
| Cell movement | 2.18 × 10-8 | ADCYAP1, ANXA1, CASP1, CDC42, CHRM3, CHRM4, CXCL10, CXCL13, EGR1, FCGR2A, FER, FGB, FGFR1, GNAZ, GRID2, HGF, HLA-G, HSP90AB1, IGF2R, JAK2, LCN2, LGALS9, LIMS1, MAP2K5, MST1, NOS3, NOS2A, OLR1, PDGFA, RARA, REG3A, SDC2, ST6GAL1, STAT1, TIMP1, TPM3, TUBB, VDR, VIPR1 | 7.96x10-5 | ADAM17, AGTR1, APCS, BDNF, CALCA, CASP1, CD44, CHRM3, DDR1, FN1, GJB2, GNAZ, GRID2, LCAT, LIMS1, NAP1L4, NPPC, NRG1, PDE4B, PPIA, PTPN11, SCN2B, SELP, SLC1A3, TAC1, TGFB1, TPM1 |
| Chemotaxis | 4.05 × 10-4 | ANXA1, CDC42, CXCL10, CXCL13, FCGR2A, FER, FGFR1, GNAZ, HGF, IGF2R, LGALS9, NOS3, VIPR1 | 6.29x10-5 | AGTR1, BDNF, CALCA, CD44, FN1, GNAZ, NAP1L4, PDE4B, PPIA, PTPN11, SCN2B, TAC1, TGFB1 |
| Cell-To-Cell Signaling and Interaction | ||||
| Adhesion of cells | 1.47 × 10-7 | ANXA1, CDC42, CDH17, CXCL10, EGR1, FCGR2A, FER, FEZ1, FGB, FGFR1, FGG, GRID2, HGF, IGF2R, ITGA7, JAG2, LGALS9, LIMS1, NOS3, OLR1, REG3A, SDC2, ST6GAL1, STAT1, STX4, TIMP1 | 1.34x10-4 | ACHE, ADAM17, CASK, CD44, CNTN4, DDR1, DLG1, FGG, FN1, GRID2, LIMS1, NRG1, PTPN11, SELP, STX4, TAC1, TGFB1, TPH1 |
| Cell Signaling | ||||
| Quantity of calcium | 3.25 × 10-3 | ADCYAP1, AVP, CHRM3, CXCL10, CXCL13, FCGR2A, GHRH, HGF, NOS3, NOS2A, VDR | 8.89x10-6 | AGTR1, BDNF, CALCA, CHRM3, FN1, GRK5, NPPC, PLD2, PPIA, PTHR1, PTPN11, SELP, TAC1, TGFB1 |
| Production of nitric oxide | 1.33 × 10-3 | IRF1, JAK2, MST1, NOS3, NOS2A, STAT1 | - | - |
| Flux of calcium | 1.67 × 10-3 | ADCYAP1, ANXA1, AVP, CHRM3, CXCL10, CXCL13, FCGR2A, P2RX2 | 2.20x10-3 | CALCA, CHRM3, FN1, NPPC, P2RX2, PPIA, TGFB1 |
| Cell surface receptor linked signal transduction | 1.45 × 10-3 | ACVR2A, ANXA1, CDC42, CXCL10, FCGR2A, FGFR1, ITGA7, JAK2, KLF6, LIMS1, PDGFA, PTPRD, STAT1 | - | - |
| Small Molecule Biochemistry | ||||
| Quantity of cyclic AMP | 1.00 × 10-5 | ADCYAP1, AVP, CHRM4, CXCL10, GAP43, GHRH, GNAZ, NOS3, VIPR1 | 6.03x10-3 | BDNF, CALCA, GNAZ, NPPC, PTHR1 |
| Production of cyclic AMP | 2.17 × 10-4 | ADCYAP1, AVP, GHRH, GNAZ, NOS3, NOS2A, VIPR1 | ||
| Accumulation of cyclic AMP | 1.21 × 10-3 | ADCYAP1, AVP, AVPR2, CHRM3, GHRH, VIPR1 | 4.35 × 10-4 | CALCA, CHRM3, GRK5, PTHR1, TAC1, TGFB1 |
| Formation of cyclic AMP | 1.28 × 10-4 | ADCYAP1, AVP, AVPR2, GHRH, GANZ | 7.26 × 10-4 | CALCA, GNAZ, PTHR1, TAC1 |
| Release of Ca2+ | 9.82 × 10-5 | ANXA1, AVP, CHRM3, FCGR2A, FGB, FGG | - | - |
| Quantity of cholesterol | - | - | 2.85 × 10-3 | ATP7B, BDNF, CALCA, GULO, LCAT |
| Post-Translational Modification | ||||
| Modification of protein | 1.57 × 10-5 | AVP, BRCA1, CASP1, CHRM3, FCGR2A, FER, FGFR1, GRID2, HSP90AB1, HTATIP, JAK2, LHB, MST1, NOS3, NOS2A, PDGFA, PDIA2, PDP2, PIM3, PTPRD, ST6GAL1, STAT1, TGM1 | 4.47 × 10-3 | APCS, CASP1, CD44, CHRM3, DUSP6, FN1, GRID2, NDST1, NRG1, PDIA3, PPIA, PTPN11, RABGGTA, TAC1, UBB |
| Nervous system development and function | ||||
| growth of neurites | 8.02 × 10-3 | ADCYAP1, CDC42, GAP43, HGF, TPM3 | - | - |
| survival of neurons | 3.60 × 10-3 | ADCYAP1, BCL2L11, GDF15, HGF, RARA, REG3A | - | - |
| development of synapse | 6.57 × 10-3 | GRID2, NFASC | - | - |
| fasciculation of axons | 3.14 × 10-2 | GAP43 | - | - |
| complexity of dendritic trees | 1.25 × 10-2 | HGF | - | - |
| long-term potentiation of dentate gyrus | 1.25 × 10-2 | EGR1 | - | - |
| neurological process of synapse | - | - | 1.60 × 10-4 | BDNF, CHRM3, CHRNB1, NRG1, PPP1R1A |
| synaptic transmission | - | - | 2.88 × 10-4 | BDNF, CACNB2, CHRM3, CHRNB1, GABRG2, P2RX2, SCN2B, SLC1A1, SLC1A3 |
| neurological process of axons, neurites | - | - | 4.79 × 10-4 | BDNF, CNTN4, GRID2, NRG1, PDIA3, UBB |
| activation of nerves | - | - | 7.73 × 10-4 | CALCA, TAC1 |
| binding of neurites | - | - | 7.73 × 10-4 | BDNF, CD44 |
| size of cell body | - | - | 7.73 × 10-4 | ACHE, BDNF |
| survival of neurons | - | - | 8.92 × 10-4 | BDNF, GDF15, NRG1, PDIA3, SLC1A3, TGFB1 |
| development of neurites | - | - | 2.83 × 10-3 | ACHE, BDNF, GRID2, NRG1, PDIA3, PTPN11 |
| migration of nervous tissue cell lines | - | - | 3.38 × 10-3 | NRG1, TGFB1 |
| proliferation of nervous tissue cell lines | - | - | 6.67 × 10-3 | NPPC, TGFB1 |
-, no subcategories found in IPA Tool; p-values and gene symbols are from IPA Tool