Table 6.
Comparison of commonly regulated gene families in PACAP-stimulated sympathetic primary neurons versus IL-induced PC12 cells (data derived from [53])
| PACAP-stimulated sympathetic neurons (data are from [53]) | IL-6-stimulated PC12 cells | |||
| Gene family | ||||
| Gene abbreviation | 9 hours | 96 hours | Gene abbreviation | 24 hours |
| Pituitary adenylate cyclase activating polypeptide | ||||
| ADCYAP1 | + | + | ADCYAP1 | + |
| BCL2-like protein | ||||
| BCL2L11 | + | n.c. | BCL2L11 | + |
| Chemokine Ligands | ||||
| CXCL1 | + | + | ||
| CXCL10 | + | |||
| CXCL13 | + | |||
| Cytochrome P450 proteins | ||||
| CYP1B1 | + | + | ||
| CYP4F16 | + | |||
| Early growth response | ||||
| EGR1 | + | n.c. | EGR1 | + |
| Glutathione S-transferase | ||||
| GSTA3 | + | n.c. | GSTA3 | - |
| Heat shock proteins | ||||
| HSP27B1 | + | n.c. | HSP90B1 | + |
| Janus kinase | ||||
| JAK2 | + | JAK2 | + | |
| Kruppel-like factors | ||||
| KLF4 | + | n.c. | KLF6 | + |
| KLF9 | + | n.c. | ||
| Nuclear factors | ||||
| NFIA | + | n.c. | NFIB | + |
| Nuclear receptors | ||||
| NR4A3 | + | n.c. | ||
| NR4A2 | + | n.c. | ||
| NR4A1 | + | n.c. | ||
| NR3C2 | + | |||
| Sialytransferases | ||||
| ST8SIA1 | + | + | ST8SIA3 | - |
| ST6GAL1 | + | + | ST6GAL1 | + |
| Solute carrier proteins | ||||
| SLC1A3 | + | n.c. | ||
| SLC2A1 | + | |||
| SLC2A3 | + | + | ||
| SLC6A3 | + | |||
| SLC7A1 | + | + | ||
| SLC7A3 | + | |||
| SLC12A5 | - | |||
| SLC18A2 | + | + | ||
| SLC30A2 | - | |||
| SLC24A2 | + | |||
| Tubulins | ||||
| TUBA1 | - | n.c. | ||
| TUBB | + | |||
| Tissue Inhibitor of metalloproteinase | ||||
| TIMP1 | + | + | TIMP1 | + |
+, upregulated -, downregulated; n.c., not changed from control cultures; gene symbols are from IPA Tool