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. Author manuscript; available in PMC: 2010 Mar 15.
Published in final edited form as: Cancer Res. 2009 Mar 10;69(6):2400–2407. doi: 10.1158/0008-5472.CAN-08-4312

Figure 6.

Figure 6

Down-regulation of Notch-2 and Jagged-1 inhibited cell migration and invasion, and reduce attachment and detachment of GR cells. Abbreviations: GS, Gemcitabine-sensitive; GR, gemcitabine-resistant. CS, control siRNA; NS, Notch-2 siRNA; JS, Jagged-1 siRNA. *, P<0.05, **, P<0.01 compared with control.

A: GR cells showed increased cell attachment and detached.

B: Down-regulation of Notch-2 or Jagged-1 in GR cells dramatically decreased the attachment and detachment of cells.

C: Transfection of GR cells with Notch-2 siRNA or Jagged-1 siRNA inhibited the migration and invasion.