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. Author manuscript; available in PMC: 2010 Feb 7.
Published in final edited form as: J Proteome Res. 2009 Feb;8(2):787–797. doi: 10.1021/pr800538n

Figure 1.

Figure 1

General description of mass spectrometry based targeted quantitative strategy. The approach consists of three major components: generation of stable isotope labeled peptides/proteins as references for the corresponding targeted protein; an effective sample preparation protocol to reduce sample complexity and enrich the targeted surrogates; a data-driven highly specific mass spectrometry platform for candidate-based analysis. More details of each aspect will be discussed in the following sections.