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. Author manuscript; available in PMC: 2010 Feb 27.
Published in final edited form as: Biochem Biophys Res Commun. 2009 Jan 21;380(1):98–104. doi: 10.1016/j.bbrc.2009.01.041

Table 1.

Kinase inhibitors and their inhibitory constants

Kinase Inhibitor Designation Inhibition Constant Concentration Used Reference
AMPK Compound C Ki=109nM 1μM [14]
STAT3 S3I-201 Inhibits STAT3-dependent tumor growth at 100μM 100μM [15]
PI3K 522DB13D IC50=4.5μM 20μM [16]
Akt 1L6HCI IC50=5μM 10μM [17]
p38 24C44F5P IC50=35nM 100nM [18]

Kinase inhibitors were used within the present cell culture model at or in excess of previously identified inhibitory concentrations. In addition, the PPARγ antagonist, G3335 (KD=8μM), was applied at 30μM [19]. Concentration-dependent inhibition of the target kinases were confirmed by immunoblot (data not shown).