TABLE 2.
APOA1 gene −75 and +83 MspI polymorphism genotype frequencies in gallstone patients and controls
| Genotype |
Total |
Male |
Female |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient (n=208), n (%) | Control (n=317), n (%) | P | OR (95% CI) | Patient (n=68), n (%) | Control (n=115), n (%) | P | OR (95% CI) | Patient (n=140), n (%) | Control (n=202), n (%) | P | OR (95% CI) | |
| APOA1 −75 guanine (G) to adenine (A) polymorphism | ||||||||||||
| GG | 135 (64.90) | 172 (54.26) | 0.015 | 1.559 (1.087–2.236) | 51 (75.00) | 61 (53.04) | 0.003 | 2.656 (1.373–5.138) | 84 (60.00) | 111 (54.95) | 0.354 | 1.230 (0.794–1.904) |
| GA | 70 (33.65) | 126 (39.75) | 0.158 | 0.769 (0.534–1.108) | 16 (23.53) | 45 (39.13) | 0.031 | 0.479 (0.244–0.939) | 54 (38.57) | 81 (40.10) | 0.776 | 0.938 (0.603–1.459) |
| AA | 3 (1.44) | 19 (5.99) | 0.011 | 0.230 (0.067–0.786) | 1 (1.47) | 9 (7.83) | 0.094 | 0.176 (0.022–1.419) | 2 (1.43) | 10 (4.95) | 0.133 | 0.278 (0.060–1.290) |
| APOA1 M2+/− | ||||||||||||
| M2+/+ | 192 (92.31) | 287 (90.54) | 0.483 | 1.254 (0.666–2.364) | 65 (95.59) | 103 (89.57) | 0.151 | 2.524 (0.686–9.287) | 127 (90.71) | 184 (91.09) | 0.905 | 0.956 (0.452–2.020) |
| M2+/− | 15 (7.21) | 26 (8.20) | 0.679 | 0.870 (0.449–1.685) | 3 (4.41) | 10 (8.70) | 0.377 | 0.485 (0.129–1.826) | 12 (8.57) | 16 (7.92) | 0.829 | 1.090 (0.499–2.381) |
| M2−/− | 1 (0.48) | 4 (1.26) | 0.653 | 0.378 (0.042–3.406) | 0 (0.00) | 2 (1.74) | 0.530 | – | 1 (0.71) | 2 (0.99) | 1.000 | 1.130 (0.505–2.528) |
−75 75 base pairs upstream; APOA1 Apolipoprotein A1;