TABLE 3.
APOA1 gene −75 and +83 MspI polymorphism allele frequencies in gallstone patients and controls
| Allele |
Total |
Male |
Female |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient (n=416)*, n (%) | Control (n=634)*, n (%) | P | OR (95% CI) | Patient (n=136)*, n (%) | Control (n=230)*, n (%) | P | OR (95% CI) | Patient (n=280)*, n (%) | Control (n=404)*, n (%) | P | OR (95% CI) | |
| APOA1 −75 guanine (G) to adenine (A) polymorphism | ||||||||||||
| G | 340 (81.73) | 470 (74.13) | 0.004 | 1.561 (1.150–2.119) | 118 (86.76) | 167 (72.61) | 0.002 | 2.473 (1.392–4.392) | 222 (79.29) | 303 (75.00) | 0.192 | 1.276 (0.884–1.840) |
| A | 76 (18.27) | 164 (25.87) | 0.004 | 0.641 (0.472–0.870) | 18 (13.24) | 63 (27.39) | 0.002 | 0.404 (0.228–0.718) | 58 (20.71) | 101 (25.00) | 0.192 | 0.784 (0.543–1.131) |
| APOA1 M2+/− | ||||||||||||
| M2+ | 399 (95.91) | 600 (94.64) | 0.347 | 1.330 (0.733–2.413) | 133 (97.79) | 216 (93.91) | 0.088 | 2.873 (0.811–10.186) | 266 (95.00) | 384 (95.05) | 0.977 | 0.990 (0.491–1.994) |
| M2− | 17 (4.09) | 34 (5.36) | 0.347 | 0.752 (0.414–1.364) | 3 (2.21) | 14 (6.09) | 0.088 | 0.348 (0.098–1.234) | 14 (5.00) | 20 (4.95) | 0.977 | 1.011 (0.501–2.036) |
*
Total number of chromosomes. −75 75 base pairs upstream; APOA1 Apolipoprotein A1