TABLE 5.
APOA1-C3 haplotype frequencies in gallstone patients and controls
| Haplotype, males | Patients (frequency), n=128 | Controls (frequency), n=226 | P | OR |
95% CI |
|
|---|---|---|---|---|---|---|
| Lower | Upper | |||||
| G-M2+-S1 | 0.56 | 0.44 | 0.04 | 1.59 | 1.03 | 2.46 |
| G-M2+-S2 | 0.31 | 0.23 | 0.11 | 1.49 | 0.92 | 2.42 |
| G-M2−-S1 | 0.02 | 0.04 | 0.37 | 0.55 | 0.15 | 2.05 |
| G-M2−-S2 | 0.00 | 0.01 | 0.35 | – | – | – |
| A-M2+-S1 | 0.11 | 0.25 | 0.00 | 0.37 | 0.20 | 0.69 |
| A-M2+-S2 | 0.00 | 0.01 | 0.15 | – | – | – |
| A-M2−-S1 | 0.00 | 0.02 | 0.19 | – | – | – |
| A-M2−-S2 | 0.00 | 0.00 | – | – | – | – |
| Haplotype, females | Patients (frequency), n=266 | Controls (frequency), n=398 | P | OR |
95% CI |
|
|---|---|---|---|---|---|---|
| Lower | Upper | |||||
| G-M2+-S1 | 0.476 | 0.466 | 0.803 | 1.040 | 0.762 | 1.420 |
| G-M2+-S2 | 0.287 | 0.249 | 0.274 | 1.215 | 0.857 | 1.724 |
| G-M2−-S1 | 0.039 | 0.037 | 0.923 | 1.041 | 0.462 | 2.346 |
| G-M2−-S2 | 0.000 | 0.000 | – | – | – | – |
| A-M2+-S1 | 0.185 | 0.220 | 0.274 | 0.805 | 0.545 | 1.188 |
| A-M2+-S2 | 0.011 | 0.018 | 0.492 | 0.622 | 0.159 | 2.438 |
| A-M2−-S1 | 0.000 | 0.011 | 0.091 | – | – | – |
| A-M2−-S2 | 0.003 | 0.000 | 0.286 | – | – | – |
A Adenine; APOA1-C3 Apolipoprotein A1-C3; G Guanine; S1 Allele with no SstI restriction site; S2 Allele with an SstI restriction site