Table 1.

Dose ratios

	Group 1	Group 2	Group 3	Group 4
Naloxone PR dailydose (mg)	Placebo	5 + 5	10 + 10	20 + 20
Oxycodone PRdaily dose (mg)	2 × 20, 2 × 30, 2 × 40	2 × 20, 2 × 30, 2 × 40	2 × 20, 2 × 30, 2 × 40	2 × 20, 2 × 30, 2 × 40
Oxycodone	20/placebo	20/10, 60/10, 80/10	40/20, 60/20, 80/20	40/40, 60/40
PR/naloxone	30/placebo			80/40
PR	40/placebo
Dose ratio		2 : 1, 6 : 1, 8 : 1	2 : 1, 3 : 1, 4 : 1	1 : 1, 1.5 : 1, 2 : 1

In the placebo group, patients received oxycodone PR and a placebo. Whereas treatment groups received oxycodone PR plus naloxone PR 10, 20 or 40 mg/day. PR, prolonged-release.