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. 2009 Mar 20;284(12):7495–7504. doi: 10.1074/jbc.M808643200

FIGURE 2.

FIGURE 2.

SP-A-modulated cell surface expression of CR3 but not CR4 on alveolar neutrophils. Six hours following H. influenzae infection, neutrophils were isolated from BAL and CR3 and CR4 expression was determined by flow cytometry. Sp-a–/– BAL neutrophils (solid bar) expressed much less CR3 on the cell surface than Sp-a+/+ BAL neutrophils (hatched bar). BAL neutrophil CR4 expression was similar for Sp-a–/– and Sp-a+/+ mice (panel A). In contrast, blood neutrophils obtained synchronously with BAL neutrophils 6 h following H. influenzae infection expressed similar CR3 levels in Sp-a–/– and Sp-a+/+ mice (panel B). Data are mean ± S.E. with n = 6 mice per group, *, p < 0.05 compared with Sp-a+/+ mice for all panels.