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. 2009 Mar 20;284(12):7495–7504. doi: 10.1074/jbc.M808643200

FIGURE 3.

FIGURE 3.

Exogenous SP-A enhanced CR3 expression on alveolar macrophages from Sp-a–/– mice. CR3 expression on alveolar macrophages was determined by flow cytometry 24 h after intratracheal injection of 100 μg of SP-A. SP-A treatment significantly enhanced expression of CR3 on alveolar macrophages from Sp-a–/– mice (open bar) compared with untreated Sp-a–/– (solid bar) mice (panel A). Data are mean ± S.E. with n = 8 mice per group, *, p < 0.05 compared with untreated Sp-a–/– mice. RAW cells, a mouse macrophage cell line, were treated with SP-A and CR3 surface expression determined by flow cytometry. SP-A enhanced surface expression of CR3 in a dose-dependent manner (panel B).