FIGURE 6.

Inhibitory effect of AT-56 on PGD₂ production by stab wounding in H-PGDS KO mice and therapeutic effect on antigen-induced lung inflammation in human L-PGDS TG mice. A, AT-56 was orally administered 1 h before the stab wounding, and brains were collected 10 min after the wounding. B, AT-56 was orally administered 1 h before and 24 h after the antigen exposure. The accumulated cells in the bronchoalveolar lavage fluid were collected 48 h after the antigen exposure. Data are presented as the mean ± S.E. *, p < 0.05; **, p < 0.01 as compared with the vehicle-treated group (Dunnett's test). p.o., per os. BALF, bronchoalveolar lavage fluid.