TABLE 1.

Pharmacokinetic parameters of AT-56

Route	Dose	AUCa	Cmaxb	C0c	tmaxd	t½e	BAf
	mg/kg	μg·h/ml	μg/ml	μg/ml	h	h	%
Intravenous	2	1.28		0.86	0.08	2.35
Per os	10	8.95	2.15		0.50	1.71	82.0

^aAUC, area under the concentration versus time curve from 0 to the last quantifiable time point.

^bC_max, maximal concentration.

^cC₀, initial concentration.

^dt_max, time to C_max.

^et_½, half-life.

^fBA, bioavailability = (AUC p.o. × dose i.v.)/(AUC i.v. × dose p.o.) × 100, where p.o. represents per os and i.v. represents intravenous.