TABLE 1.
IC50 of W2 and W2/MRPΔ parasites in responses to eight antimalarial drugs W2Δ is the abbreviated name for W2/MRPΔ, The IC50 values are geometric means (nm), and % Change is 100(W2Δ IC50 – W2 IC50)/W2 IC50. LCI and UCI are lower and upper confidence intervals, respectively. The p values and CIs on the % change are derived from the paired t test on the log(IC50) values. Note that CQ, QN, ART, PQ, and PRQ are significant even after correcting for multiple tests using Bonferroni's adjustment (p < 0.05).
Drug | W2/IC50 | W2Δ/IC50 | % Change | 95% LCI | 95% UCI | No. repeats | Two-sided p value |
---|---|---|---|---|---|---|---|
CQ | 163 | 101 | –38 | –45 | –31 | 8 | <0.01 |
QN | 174 | 76 | –56 | –62 | –49 | 8 | <0.01 |
AMQ | 67 | 60 | –10 | –21 | 3 | 4 | 0.01 |
MQ | 12 | 11 | –7 | –22 | 11 | 8 | 0.37 |
ART | 11 | 5 | –57 | –61 | –52 | 9 | <0.01 |
PQ | 138 | 82 | –40 | –50 | –29 | 4 | <0.01 |
PG | 104 | 64 | –38 | –75 | 53 | 4 | 0.19 |
PRQ | 2660 | 1243 | –53 | –63 | –42 | 4 | <0.01 |