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. 2009 Mar 20;284(12):7687–7696. doi: 10.1074/jbc.M806944200

TABLE 1.

IC50 of W2 and W2/MRPΔ parasites in responses to eight antimalarial drugs W2Δ is the abbreviated name for W2/MRPΔ, The IC50 values are geometric means (nm), and % Change is 100(W2Δ IC50 – W2 IC50)/W2 IC50. LCI and UCI are lower and upper confidence intervals, respectively. The p values and CIs on the % change are derived from the paired t test on the log(IC50) values. Note that CQ, QN, ART, PQ, and PRQ are significant even after correcting for multiple tests using Bonferroni's adjustment (p < 0.05).

Drug W2/IC50 W2Δ/IC50 % Change 95% LCI 95% UCI No. repeats Two-sided p value
CQ 163 101 –38 –45 –31 8 <0.01
QN 174 76 –56 –62 –49 8 <0.01
AMQ 67 60 –10 –21 3 4 0.01
MQ 12 11 –7 –22 11 8 0.37
ART 11 5 –57 –61 –52 9 <0.01
PQ 138 82 –40 –50 –29 4 <0.01
PG 104 64 –38 –75 53 4 0.19
PRQ 2660 1243 –53 –63 –42 4 <0.01
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