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UBQLN coaggregates with non-overlapping fragments of TDP-43. A, schematic depiction of TDP-43 deletion mutants. B, colocalization analysis of UBQLN with TDP-43 deletion mutants. HeLa cells were cotransfected with wild-type or mutant HA-TDP-43 plasmids and Myc-UBQLN and stained with α-TDP-43 and α-UBQLN antibodies. Representative images (×100) for each mutant are shown.
