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Model recapitulating the roles played by SUG-1 in the control of RARα target genes. A, in response to RA, SUG-1 interacts with SRC-3 and thereby fine-tunes RARα-mediated transcription. It also contributes to the proteasomal degradation of SRC-3. B, when present in excess amounts, SUG-1 accelerates the degradation of SRC-3. It also blocks the AF-2 domain of RARα and impedes the recruitment of SRC-3 and of the transcription and degradation machineries.
