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Proviral orientations for newly integrated HERVKcon versus resident HERVs. (A) Diagram showing proviral orientations and the potential for transcriptional disruption by provirus-encoded transcription signals. (SD) Splice donor; (SA) splice acceptor; (PolyA) polyA signal. (B) Transcriptional orientation of ERV2, HML2(85), and HERVKcon sequences found within gene-coding regions as defined by the RefSeq database.
