Table 1. Comparison of clinicopathological findings between FISH negative and positive gastric carcinomas.
|
ERBB2 amplification
|
|||
|---|---|---|---|
| Negative (n=218) | Positive (n=38) | P value | |
| Age (years) | 66 (±10.8) | 63 (±13.6) | NS |
| NS | |||
| Sex | |||
| Male | 127 (58.3%) | 18 (47.4%) | |
| Female | 91 (41.7%) | 20 (52.6%) | |
| Histopathological classification(s) | |||
| Lauren | 0.007 | ||
| Intestinal | 121 (55.5%) | 31 (81.6%) | |
| Diffuse | 63 (28.9%) | 3 (7.9%) | |
| Non classified | 34 (15.6%) | 4 (10.5%) | |
| Carneiro | 0.013 | ||
| Glandular | 119 (54.5%) | 31 (81.6%) | |
| Isolated cells | 62 (28.4%) | 3 (7.9%) | |
| Solid | 5 (2.3%) | 2 (5.3%) | |
| Mixed | 28 (12.8%) | 2 (5.3%) | |
| Non classified | 4 (1.8%) | ||
| Ming | 0.021 | ||
| Expansive | 56 (26%) | 18 (47.4%) | |
| Infiltrative | 153 (71.2%) | 20 (52.6%) | |
| Mixed | 6 (2.8%) | — | |
| Venous invasion | NS | ||
| Positive | 147 (68%) | 24 (63.2%) | |
| Negative | 69 (32%) | 14 (36.8%) | |
| Nodal metastases a | NS | ||
| N0 | 73 (34%) | 9 (23.7%) | |
| N+ | 142 (66%) | 29 (76.3%) | |
| Clinical stage a | NS | ||
| 0–IA | 26 (12.1%) | 2 (5.3%) | |
| IB | 21 (9.8%) | 3 (7.9%) | |
| II | 41 (19%) | 7 (18.4%) | |
| IIIA | 50 (23.3%) | 10 (26.3%) | |
| IIIB | 35 (16.3%) | 7 (18.4%) | |
| IV | 42 (19.5%) | 9 (23.7%) | |
| Type of surgery a | NS | ||
| Curative | 141 (72.3%) | 23 (67.6%) | |
| Palliative | 54 (27.7%) | 11 (32.4%) | |
NS=non significant.
a
Missing cases due to lack of clinical information.