Figure 2.

Pathway analysis of direct interactions between selected nucleolar proteins, and other nuclear and cytoplasmic proteins. This interaction map was generated using Ingenuity Pathway Analysis software (Ingenuity Systems, Inc., Redwood City, CA, USA), and shows the complexity of the interactions—many of which are interlinked—and how perturbations to one protein might affect the function of another. Examples of proteins that can traffic to the nucleolus and that are discussed in the text, such as VHL, are also shown. The full names of all of the proteins that are shown on the map can be found in supplementary Table 1 online. FBL, fibrillarin; NCL, nucleolin; NPM1, nucleophosmin; VHL, von Hippel–Lindau tumour-suppressor protein.