Skip to main content
. Author manuscript; available in PMC: 2010 Feb 7.
Published in final edited form as: J Proteome Res. 2009 Feb;8(2):471–482. doi: 10.1021/pr800667a

Figure 1.

Figure 1

Method Overview.

The use of Con-A lectin-affinity chromatography coupled to 2D electrophoresis allows the separation and the resolution of Con-A-associated proteins.

Alzheimer’s disease (AD) is the most common type of dementia, comprising 60–80% of all reported cases, and currently affects 5.2 million Americans. Mild cognitive impairment (MCI) arguably is the earliest for of AD. The present study identifies Con-A-fractionated brain proteins AD and MCI in two brain regions. The identity of proteins with altered levels in AD and MCI brain are consistent with biochemical and/or pathological alterations in both disorders.