Table 3.
Summary of MALDI/TOF mass spectrometry-based characterizations and hippocampal protein identifications of Con-A-fractionated proteins from MCI and AD
| NCBI GI no. | NCBI accession no. | Protein | # of Peptides matched/searched | Percent coverage of the matched peptides | pI, Mr (kDa) | Mowse | Fold Increase/Decrease | P-Value | Disorder |
|---|---|---|---|---|---|---|---|---|---|
| 4503377 | NM_001386.4 | Dihydropyrimdase-2 (spot A) | 7/23 | 26% | 4.84, 41,653 | 99 | 1.72 decrease | 0.04 | MCI |
| 4503377 | NM_001386.4 | Dihydropyrimdase-2 (spot B) | 12/38 | 27% | 4.84, 41,653 | 166 | 3.82 decrease | 0.02 | MCI |
| 386758 | M19645.1 | Glucose-regulated protein-78 | 14/40 | 25% | 5.03, 72,185 | 117 | 1.51 decrease | 0.05 | MCI |
| 4506013 | NM_002712.1 | Protein phosphatase related protein SDS-22 | 7/23 | 26% | 4.84, 41,653 | 68 | 2.26 increase | 0.05 | MCI |
| 4503979 | NM_002055.3 | Glial fibrillary acidic protein | 20/42 | 39% | 5.84, 49,533 | 187 | 17.1 increase | 0.05 | MCI |
| 4885281 | NM_005271.2 | Glutamate Dehydrogenase | 15/33 | 32% | 7.66, 61,701 | 142 | 3.2 increase | 0.03 | AD |
| 4885281 | NM_005271.2 | Glutamate Dehydrogenase | 14/26 | 29% | 7.66, 61,701 | 147 | 2.6 increase | 0.03 | AD |
| 4503979 | NM_002055.3 | Glial fibrillary acidic protein | 13/18 | 32% | 5.84, 49,533 | 158 | 16.0 increase | 0.05 | AD |
| 109016549 | XM_001113666.1 | Tropomyosin-3 | 11/29 | 34% | 4.71, 29,019 | 106 | 2.0 increase | 0.02 | AD |
| 4503971 | NM_001493.2 | Rab GDP-dissociation inhibitor XAP-4 | 9/26 | 25% | 5.00, 51,177 | 83 | 6.0 decrease | 0.03 | AD |
| 4503971 | NM_001493.2 | Rab GDP-dissociation inhibitor XAP-4 | 14/35 | 34% | 5.00, 51,177 | 136 | 1.6 decrease | 0.03 | AD |
| 153792590 | NM_001017963.2 | Heat shock protein 90 | 18/40 | 31% | 5.11, 68,614 | 128 | 1.7 decrease | 0.04 | AD |