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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: J Immunol. 2009 Feb 15;182(4):1789–1793. doi: 10.4049/jimmunol.0803200

Figure 3. The SJL/J Y Chr controls EAE severity in SJL/J males.

Figure 3

Active EAE was induced in 6–8 wk old SJL/J mice with PLP139–151-CFA on days 0 and 7. (A) The clinical course of EAE differed significantly between SJL.YB10.S (n = 20) and SJL/J mice (n = 9) (time effect, p < 0.01; group effect, p < 0.01; interaction term, p < 0.01). (B) Ten days after injection, splenocytes and lymphocytes were stimulated with 50 µg/ml PLP139–151 and cytokine production measured by ELISA. Mean and SD are show. Statistically significant differences by Student’s t-test are indicated (*, p < 0.05; n = 6).