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. Author manuscript; available in PMC: 2010 Feb 17.
Published in final edited form as: Circulation. 2009 Feb 2;119(6):835–844. doi: 10.1161/CIRCULATIONAHA.108.815043

Figure 4.

Figure 4

Cardioprotective effects of adiponectin are blunted but not lost in AMPK-DN mice. Mean values obtained from vehicle-treated MI/R animals were treated as 100%, and individual values from each animal were normalized against the mean values. Myocardial infarct size was determined by Evans blue/TTC double staining (A, n=12 to 14 hearts per group). Myocardial apoptosis was determined by TUNEL labeling (B, n=5 to 6 hearts per group), DNA ladder formation (C, n=4 to 6 hearts per group; lane 1=sham MI/R, lane 2=MI/R+vehicle, lane 3=MI/R+gAPN), and caspase 3 activation (D, n=10 to 12 hearts per group). *P<0.05, **P<0.01 vs MI/R+vehicle; #P<0.05 vs WT mice treated with adiponectin.