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. Author manuscript; available in PMC: 2009 Sep 15.
Published in final edited form as: Cancer Res. 2009 Feb 24;69(6):2393–2399. doi: 10.1158/0008-5472.CAN-08-4264

Figure 3. Lethal DNA lesions induced by H2O2 oxidation of DNA 6-TG are not excised by NER.

Figure 3

SV40 transformed GM04429f (circles) or MRC5-VA (squares) cells were cultured for 48h in 0.5μM 6-TG then treated with H2O2 for 1h. Clonal survival was determined. Solid lines: no 6-TG treatment. Dashed lines: + 6-TG treatment.

Data are the mean ± SD of 4 independent experiments.

Insert. Confirmation of the XP phenotype. Cells not treated with 6-TG were irradiated with UVC at the doses indicated and survival determined as above.