TABLE 6.
EUVAS GRADING OF DISEASE SEVERITY
| Clinical Class | Constitutional Symptoms | Renal Function | Threatened Vital Organ Function | Options for Induction Therapy |
|---|---|---|---|---|
| Limited | No | Creatinine < 120 μmol/l (1.4 mg/dl) | No | Corticosteroids OR methotrexate OR azathioprine |
| Early generalized | Yes | Creatinine < 120 μmol/l (1.4 mg/dl) | No | Cyclophosphamide OR methotrexate + corticosteroids |
| Active generalized | Yes | Creatinine < 500 μmol/l (5.7 mg/dl) | Yes | Cyclophosphamide + corticosteroids |
| Severe | Yes | Creatinine > 500 μmol/l (5.7 mg/dl) | Yes | Cyclophosphamide + corticosteroids + plasma exchange |
| Refractory | Yes | Any | Yes | Consider investigational agents |