Table 5.
Sporozoite formation in crosses of sporulation-deficient mutants with male- and female-deficient mutants.
| Oocysts | Sporozoites | |||||||
|---|---|---|---|---|---|---|---|---|
| KO clone | Gametocyte donor | Prev. (%) | n | Mean | SEM | n | Mean | Infectivity to micea |
| Male | ||||||||
| Δasp | Δpbs47 | 100 | 20 | 46 | 4 | 20 | 0 | n.d. |
| Δasp | Δpbs47 | 100 | 10 | 109 | 18 | 30 | 66 | 0/2 |
| Δasp | Δpbs47 | 100 | 10 | 158 | 29 | 30 | 0 | n.d. |
| Δlap5 | Δpbs47 | 100 | 10 | 83 | 19 | 31 | 37 | 0/1 |
| Δlap5 | Δnek4 | 100 | 8 | 53 | 29 | 19 | 156 | 0/1 |
| Δlap5 | Δnek4 | 100 | 10 | 68 | 7 | 30 | 59 | 0/1 |
| Δpsop13 | Δpbs47 | 100 | 10 | 34 | 9 | 30 | 140 | 0/1 |
| Δpsop13 | Δnek4 | 90 | 10 | 62 | 10 | 30 | 76 | n.d. |
| Δpsop13 | Δnek4 | 83 | 10 | 32 | 11 | 30 | 103 | 1/1b |
| Female | ||||||||
| Δasp | Δpbs48/45 | 100 | 20 | 210 | 21 | 20 | 5 209 | n.d. |
| Δasp | Δpbs48/45 | 93 | 10 | 101 | 26 | 30 | 28 810 | 2/2 |
| Δasp | Δpbs48/45 | 100 | 10 | 54 | 7 | 30 | 13 443 | n.d. |
| Δlap5 | Δpbs48/45 | 100 | 10 | 129 | 17 | 18 | 15 618 | 1/1 |
| Δlap5 | Δpbs48/45 | 96 | 10 | 89 | 14 | 30 | 3 551 | 1/1 |
| Δlap5 | Δpbs48/45 | 100 | 10 | 96 | 15 | 27 | 7 258 | 1/1 |
| Δpsop13 | Δpbs48/45 | 97 | 10 | 25 | 10 | 30 | 13 740 | 1/1 |
| Δpsop13 | Δpbs48/45 | 100 | 10 | 52 | 7 | 30 | 7 598 | n.d. |
a
Number of mice infected/number of mice used.
b
Δpsop13 allele not transmitted.
Prev., prevalence; n.d., not done.