Table 1.

Validated and hypothetic miRNA targets

Validated miRNA targets in type 2 diabetes and in the endocrine system
miRNA	Target	Function	Reference
miR-375	Myotrophin	Inhibition of insulin secretion	[69]
miR-9	OneCut2 transcription factor	Inhibition of glucose-stimulated insulin release	[70]
miR-192	E-box repressors	TGF-beta-induced matrix protein collagen Col1a1 and -2	[24]
miR-143	GLUT4, HSL, fatty acid-binding protein aP2, PPAR-μ2	Adipocyte differentiation	[49]
Hypothetic miRNA targets associated with type 2 diabetes
miR-30 family	Receptor for advanced glycation end product, immediate early response 3, vimentin, heat-shock protein-20	Podocyte apoptosis and cytoskeletal structure	[79,80]
miR-23b	Hairy/enhancer of the split protein (Hes1)	Downstream target of activated Notch signalling and expressed in nephron segments during development	[81,84]
miR-15, miR-16	Wnt and β-catenin	Nephron induction during embryo development	[75,76]
miR-7	GY-box	Notch signalling	[73,74]
miR-4, miR-79	Brd-box
miR-2, miR-11	K-box