Table 5.
Matrix effects. Artemisinin (ARN) and internal standard (ARS) spiked in extracted blank human plasma vs. spiked in elution solution.
| Blank A | Blank B | Blank C | Blank D | Blank E | Blank F | Average | S.D. | CV (%) | |
|---|---|---|---|---|---|---|---|---|---|
| ARN (QC1): 2.89 ng/mL | 105 | 107 | 110 | 106 | 101 | 108 | 106 | 3.0 | 2.9 |
| ARS (QC1): 20.4 ng/mL | 109 | 110 | 106 | 108 | 109 | 116 | 110 | 3.4 | 3.1 |
| Normalized response | 0.96 | 0.98 | 1.04 | 0.99 | 0.93 | 0.93 | 0.97 | 0.04 | 4.1 |
| ARN (QC3): 571 ng/mL | 102 | 108 | 106 | 107 | 106 | 108 | 106 | 2.2 | 2.1 |
| ARS (QC3): 20.4 ng/mL | 109 | 107 | 112 | 115 | 112 | 116 | 112 | 3.4 | 3.0 |
| Normalized response | 0.93 | 1.01 | 0.94 | 0.92 | 0.95 | 0.93 | 0.95 | 0.03 | 3.3 |