Table I.
Time, h | r2 | Median Prediction Error (Residual)a (90% CI) | Mean Squared Prediction Errorb (90% CI) | MRT Phase 1c (90% CI) |
---|---|---|---|---|
.5 | 0.889 | -5.75 (-20, 20) | 1874 (993-2756) | |
1 | 0.938 | 1.67 (-15, 15) | 1044.75 (380-1710) | |
1.5 | 0.966 | -2.11 (-11, 11) | 575 (108-1042) | |
2 | 0.918 | 0.52 (-17, 17) | 1381 (382-2380) | |
2.5 | 0.956 | 0.75 (-12, 12) | 740 (116-1364) | |
3 | 0.948 | 2.11 (-14, 14) | 560 (207-912) | |
3.5 | 0.978 | -0.43 (-9, 9) | 36 (153-579) | |
4 | 0.984 | -1.22 (-7, 7) | 244 (61-428) | |
5 | 0.976 | 0.38 (-9, 9) | 395 (136-655) | |
6 | 0.978 | 1.46 (-9, 9) | 368 (103-635) | |
8 | 0.983 | -3.59 (-8, 8) | 278 (87-468) | |
24 | 0.903 | -4.02 (-19, 19) | 1644 (904-2383) | |
3.47 h (3.11-3.82) | ||||
Optimal sampling time, h | 4 | 5 | 3.5 | 3.5 |
CI, confidence interval; MRT, mean residence time.
Median prediction error: median value of the sum of individual prediction errors (AUCpred - AUC0-∞).
Mean squared prediction error: mean value of the sum of individual squared prediction errors.
Mean residence time: average of individual subjects' MRTs obtained prior to Ginkgo biloba extract administration.