Table 1.

In vitro cytotoxic effect of betulinic acid on human cancer cell lines.

Cancer type	ED50 (μg/ml)	References
melanoma	1.1–4.8	[33]
neuroblastoma	2–10	[14]
medulloblastoma	3–15	[39]
glioblastoma	5–16	[39]
head & neck cancer	8	[18]
ovarian carcinoma	1.8–4.5	[22]
cervix carcinoma	1.8	[22]
lung carcinoma	1.5–4.2	[22]
leukemia	2–15	[23]