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. Author manuscript; available in PMC: 2009 Mar 20.
Published in final edited form as: J Neurooncol. 2008 Jan 30;88(1):43–50. doi: 10.1007/s11060-008-9530-8

Table 5.

Toxicity during adjuvant temozolomide chemotherapy.

Characteristic Group 1 Adjuvant TMZ only N=21 Group 2 Concurrent & adjuvant TMZ N=22 P
Thrombocytopenia
Grade 1 3 (14%) 3 (14%)
Grade 2 0 0 0.0407
Grade 3 2 (10%) 0
Grade 4 4 (19%) 0

Leukopenia
Grade 1 4 (19%) 1 (5%)
Grade 2 0 5 (23%) 0.0685
Grade 3 1 (5%) 0
Grade 4 1 (5%) 1 (5%)

Anemia
Grade 1 1 (5%) 0
Grade 2 1 (5%) 1 (5%) 0.7379
Grade 3 0 1 (5%)
Grade 4 0 2 (9%)

Upper GI toxicity
Grade 1 5 (24%) 5 (23%)
Grade 2 1 (5%) 3 (14%) 0.5290
Grade 3 2 (10%) 0
Grade 4 0 1 (5%)

Radiation dermatitis
Grade 1 8 (38%) 4 (18%)
Grade 2 1 (5%) 3 (14%) 0.2576
Grade 3 0 0
Grade 4 0 0