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. 2008 Sep 16;337:a1440. doi: 10.1136/bmj.a1440

Table 4.

 Risk of mortality during 24 years of follow-up according to number of lifestyle risk factors in never smokers*

Death from any cause Cardiovascular death Cancer death
Three risk factors: low diet quality, low physical activity, overweight†
Relative risk (95% CI):
 No risk factors (7.7%)‡ 1.00 1.00 1.00
 One risk factor (27%) 1.20 (1.02 to 1.43) 1.44 (0.91 to 2.27) 1.19 (0.95 to 1.49)
 Two risk factors (41%) 1.54 (1.31 to 1.81) 2.24 (1.44 to 3.46) 1.37 (1.11 to 1.70)
 Three risk factors (25%) 2.17 (1.83 to 2.57) 3.58 (2.30 to 5.58) 1.75 (1.39 to 2.19)
Population attributable risk (%) for having any of the three risk factors (95% CI) 34.3 (18.9 to 48.0) 56.1 (27.7 to 75.5) 22.8 (−0.01 to 44.3)
Four risk factors: above three and alcohol abstinence or heavy drinking§
Relative risk (95% CI)
 No risk factors (5.4%)‡ 1.00 1.00 1.00
 One risk factor (20%) 1.25 (1.01 to 1.53) 1.18 (0.70 to 1.99) 1.39 (1.05 to 1.83)
 Two risk factors (34%) 1.48 (1.22 to 1.81) 1.78 (1.08 to 2.92) 1.42 (1.08 to 1.85)
 Three risk factors (30%) 1.95 (1.60 to 2.38) 2.64 (1.61 to 4.33) 1.70 (1.30 to 2.22)
 Four risk factors (10%) 2.64 (2.13 to 3.26) 3.94 (2.35 to 6.60) 2.11 (1.57 to 2.83)
Population attributable risk (%) for having any of the four risk factors (95% CI) 41.5 (24.3 to 56.2) 60.9 (28.3 to 80.9) 25.7 (−1.4 to 49.3)

*Relative risks and population attributable risks adjusted for age (5 year age categories) and time period (four periods); additionally adjusted for alcohol consumption (0, 1-4, 5-14, 15-29, ≥30.0 g/d) for the “three risk factor” model.

†Low diet quality: healthy diet score in lower three fifths; low physical activity: <30 min/day; overweight: body mass index ≥25.

‡Prevalence in 1990.

§0 or ≥15 g/day alcohol.