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. Author manuscript; available in PMC: 2010 Feb 15.
Published in final edited form as: Biochem Pharmacol. 2008 Nov 6;77(4):654–659. doi: 10.1016/j.bcp.2008.10.026

Table 2.

Sequences and positions of DREs on Cyp1a1_1a2 in human, cattle, dog and rat

Organism DRE (No.) Location from Cyp1a1 Sequence
Human 1a −497 cTcGCGTGaga
2 −892 cTtGCGTGcgc
3b −980 gTtGCGTGaga
4 −1061 cTcGCGTGact
5 −1373 tTtGCGTGcct
6 −2116 gTgGCGTGatc
7 −5604 gTgGCGTGatc
8 −12213 tTtGCGTGaga
9 −12384 cTgGCGTGagc
10 −15061 aTgGCGTGaac
11 −18617 aTaGCGTGcct
12 −20417 aTgGCGTGatc

Cattle 1a −490 cTcGCGTGaga
2 −949 cTaGCGTGcct
3b −1040 gTtGCGTGaga
4 −1118 cTcGCGTGact
5 −1273 tTtGCGTGcag
6 −4276 tTtGCGTGaga

Dog 1a −506 cTcGCGTGaga
2b −972 gTtGCGTGaga
3 −1036 tTcGCGTGaca
4 −1115 tTtGCGTGcgg
5 −4332 tTgGCGTGgag
6 −4379 tTtGCGTGaga
7 −5152 tTtGCGTGccc
8 −15797 aTtGCGTGagc
9 −17856 cTgGCGTGcca

Rat 1a −538 cTaGCGTGaga
2 −898 tTgGCGTGcac
3 −923 cTgGCGTGcgt
4b −1012 gTtGCGTGaga
5 −1089 cTaGCGTGaca
6 −1235 tTtGCGTGcaa
7 −1409 tTgGCGTGtct

Sequences and positions of DREs on human CYP1A1_CYP1A2 were referred to AF253322 (GenBank) and [15].(XRE13 was not included.) Those of DREs on cattle, dog and rat Cyp1a1_Cyp1a2 were determined by analyzing genomic contig sequeneces NC007319, NC006612 and NW047799, respectively.

a, b

Highly conserved DREs in the position and sequence among these organisms