Table 2.
Organism | DRE (No.) | Location from Cyp1a1 | Sequence |
---|---|---|---|
Human | 1a | −497 | cTcGCGTGaga |
2 | −892 | cTtGCGTGcgc | |
3b | −980 | gTtGCGTGaga | |
4 | −1061 | cTcGCGTGact | |
5 | −1373 | tTtGCGTGcct | |
6 | −2116 | gTgGCGTGatc | |
7 | −5604 | gTgGCGTGatc | |
8 | −12213 | tTtGCGTGaga | |
9 | −12384 | cTgGCGTGagc | |
10 | −15061 | aTgGCGTGaac | |
11 | −18617 | aTaGCGTGcct | |
12 | −20417 | aTgGCGTGatc | |
| |||
Cattle | 1a | −490 | cTcGCGTGaga |
2 | −949 | cTaGCGTGcct | |
3b | −1040 | gTtGCGTGaga | |
4 | −1118 | cTcGCGTGact | |
5 | −1273 | tTtGCGTGcag | |
6 | −4276 | tTtGCGTGaga | |
| |||
Dog | 1a | −506 | cTcGCGTGaga |
2b | −972 | gTtGCGTGaga | |
3 | −1036 | tTcGCGTGaca | |
4 | −1115 | tTtGCGTGcgg | |
5 | −4332 | tTgGCGTGgag | |
6 | −4379 | tTtGCGTGaga | |
7 | −5152 | tTtGCGTGccc | |
8 | −15797 | aTtGCGTGagc | |
9 | −17856 | cTgGCGTGcca | |
| |||
Rat | 1a | −538 | cTaGCGTGaga |
2 | −898 | tTgGCGTGcac | |
3 | −923 | cTgGCGTGcgt | |
4b | −1012 | gTtGCGTGaga | |
5 | −1089 | cTaGCGTGaca | |
6 | −1235 | tTtGCGTGcaa | |
7 | −1409 | tTgGCGTGtct |
Sequences and positions of DREs on human CYP1A1_CYP1A2 were referred to AF253322 (GenBank) and [15].(XRE13 was not included.) Those of DREs on cattle, dog and rat Cyp1a1_Cyp1a2 were determined by analyzing genomic contig sequeneces NC007319, NC006612 and NW047799, respectively.
Highly conserved DREs in the position and sequence among these organisms